Jeffrey S. Elmendorf, PhD

Associate ProfessorDepartments of Cellular & Integrative Physiology, and Biochemistry & Molecular BiologyCenter for Diabetes Research Indiana University School of Medicine
635 Barnhill Drive MS 308A Indianapolis, IN 46202
Research Program Membership Cellular and Molecular Metabolism
Research Description

Dr. Elmendorf's research over the past 20 years has been focused on dissecting mechanisms regulating skeletal muscle and adipose tissue glucose transport and defining their alterations in insulin resistance. A major alteration found uniformly in insulin-resistant cell systems and tissues from insulin-resistant animal models and humans is an accumulation of membrane cholesterol. Two main projects are: 1) Determining the mechanism of peripheral tissue membrane cholesterol accrual/toxicity; and 2) Identifying therapeutic reversal strategies. The projects are of direct relevance to human disease, are translational, and are expected to significantly impact understanding of new approaches to the prevention and/or treatment of disorders in glucose and lipoprotein metabolism.

PhD Albany Medical College, Albany, NY, 1996
Postdoctoral Fellowship University of Iowa, Iowa City, IA, 1999