Research Program MembershipCellular and Molecular Metabolism
Our long-standing research program includes the study of cancer and cancer treatment on the musculoskeletal system. Most recently, we have shown that TGF-b, released as a consequence of increased osteoclastic bone resorption [in states of bone metastases as well as non-malignant Camurati-Engelmann Disease (CED)], causes muscle weakness by oxidation of the skeletal muscle calcium channel ryanodine receptor (RYR). Since oxidation of RyR can impair insulin secretion, we want to determine if states of high bone turnover associated with increased systemic TGF-b also result in impaired insulin secretion and altered glucose metabolism. These studies fit in the Cellular and Molecular Metabolism as well as Islet Function and Survival.