Zhong-Yin Zhang, PhD

Robert A. Harris Professor and ChairDepartment of Biochemistry and Molecular Biology Indiana University School of Medicine
635 Barnhill Drive MS 4053A Indianapolis, IN 46202
Research Program Membership Cellular and Molecular Metabolism
Research Description

Dr. Zhang’s research spans the disciplines of chemistry and biology with an emphasis on the structure and function of protein tyrosine phosphatases (PTPs); PTP-mediated signaling; mechanistic enzymology; molecular recognition; and inhibitor design. His group performed fundamental experiments that defined the precise catalytic mechanism, rate-limiting step, and the transition state of the PTP-catalyzed reaction; probed the molecule basis for PTP substrate specificity using both structural and biochemical approaches; pioneered a novel paradigm for acquisition of potent and selective bidentate PTP inhibitors; elucidated the biochemical mechanism for the PRL3 phosphatase-mediated cell proliferation and metastasis; developed activity-based PTP probes that can be used to interrogate PTP activity in the whole proteome under both normal and type 2 diabetic, insulin resistant states; and defined the signaling mechanisms by mPTPB phosphatase.

PhD Purdue University, West Lafayette, IN, 1990
Postdoctoral Fellowship The Upjohn Company, Kalamazoo, MI, 1991University of Michigan, Ann Arbor, MI, 1994